|
KMID : 1001020110090020051
|
|
Journal of Urologic Oncology
2011 Volume.9 No. 2 p.51 ~ p.54
|
|
|
Additional Hormonal Agents for Castration Resistance Prostate Carcinoma
|
|
Seong Do-Hwan
|
|
|
Abstract
|
|
|
|
Androgen deprivation therapy(ADT) is the mainstay of systemic therapy for advanced or metastatic prostate cancer. The majority of 90% of patients respond to currently available first line ADT therapy. However, responses are transient and metastatic disease progresses as castration-resistant prostate cancer(CRPC). Traditional secondary hormonal manipulations can be of clinical benefit in some patients after primary ADT failure. Novel therapies for CRPC have demonstrated promising activity in many men with CRPC and may redefine the clinical management of these patients. This paper summarises the current clinical development of these agents as well as a brief review of hormonal strategies in CRPC.
|
|
|
KEYWORD
|
|
|
Androgen deprivation, Castration, Prostate cancer
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|